Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells.

The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic integrity and viability for all organisms. Mammals have evolved at least two genetically discrete ways to mediate DNA DSB repair: homologous recombination (HR) and non-homologous end joining (NHEJ). In mammalian...

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Bibliographic Details
Main Authors: Farjana Fattah, Eu Han Lee, Natalie Weisensel, Yongbao Wang, Natalie Lichter, Eric A Hendrickson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2829059?pdf=render

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