Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology

Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology

Granulysin is a protein present in the granules of human cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, with cytolytic activity against microbes and tumors. Previous work demonstrated the therapeutic effect of the intratumoral injection of recombinant granulysin and of the systemic inj...

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Bibliographic Details
Main Authors:	Patricia Guerrero-Ochoa, Diederich Aguilar-Machado, Raquel Ibáñez-Pérez, Javier Macías-León, Ramón Hurtado-Guerrero, Javier Raso, Alberto Anel
Format:	Article
Language:	English
Published:	MDPI AG 2020-08-01
Series:	International Journal of Molecular Sciences
Subjects:	granulysin scFv immunotoxin pulsed electric fields Tn antigen pancreatic tumors
Online Access:	https://www.mdpi.com/1422-0067/21/17/6165

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