ATRA inhibits the proliferation of DU145 prostate cancer cells through reducing the methylation level of HOXB13 gene.

ATRA inhibits the proliferation of DU145 prostate cancer cells through reducing the methylation level of HOXB13 gene.

All-trans retinoic acid (ATRA) has been widely investigated for treatments of many cancers including prostate cancer. HOXB13, silenced in androgen receptor-negative (AR(-)) prostate cancer cells, plays a role in AR(-) prostate cancer cell growth arrest. In this study we intended to elucidate the mec...

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Bibliographic Details
Main Authors: Zhiwei Liu, Guoling Ren, Chenyan Shangguan, Lijing Guo, Zhixiong Dong, Yueyang Li, Weina Zhang, Li Zhao, Pingfu Hou, Yu Zhang, Xiuli Wang, Jun Lu, Baiqu Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3396626?pdf=render

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