Histoplasmin reaction. Comparison of a polysaccharide antigen to the filtrate antigen

• Main Authors: Sérgio Di Camilo FAVA, Evandro A. RIVITTI, Luiz Carlos CUCÉ, Simone WEISS, Gianine RIGONE, Celeste FAVA-NETTO
• Format: Article
• Language: English
• Published: Universidade de São Paulo 1997-09-01
• Series: Revista do Instituto de Medicina Tropical de São Paulo
• Subjects: Reaction to histoplasmin; Filtrate antigen; Polysaccharide antigen
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651997000500003
• ISSN: 0036-4665; 1678-9946

This work was planned by taking into account all the knowledge accumulated from the immunological study of paracoccidioidomycosis. It aimed at comparing a polysaccharide antigen from Histoplasma capsulatum to a classic histoplasmin with the help of intradermal tests of delayed type of hypersensitivity. Tests were applied to 115 individuals in Santo Amaro, a town in the state of São Paulo. Positive results using classic histoplasmin were obtained in 46.0% cases whereas positive results using the polysaccharide antigen at its hightest concentration were obtained in 51.30% cases. The major conclusion in this investigation is that it is possible to use the polysaccharide antigen as histoplasmin instead of the filtrate antigen<br>O estudo envolve a comparação entre o antígeno polissacarídico de Histoplasma capsulatum com a histoplasmina clássica em inquérito epidemiológico, através de provas intradérmicas de hipersensibilidade do tipo tardio, realizado em 115 indivíduos da região de Santo Amaro. Os resultados revelaram 46,0% de provas positivas com a histoplasmina clássica e 51,30% de resultados positivos com o antígeno polissacarídico em sua maior concentração. A principal conclusão da pesquisa: é possível utilizar o antígeno polissacarídico como histoplasmina, em substituição ao antígeno filtrado