Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Abstract Background Anticitrullinated protein antibodies (ACPA) and citrullinated proteins play key roles in the pathogenesis of rheumatoid arthritis (RA). Many candidate citrullinated antigens have been identified in joints, but citrullinated proteins in sera are mostly uncertain in patients with R...

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Bibliographic Details
Main Authors: Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Yasuhiro Shinkai, Yoshito Kumagai, Akihito Ishigami, Takayuki Sumida
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Citrullinated proteins
Inter-alpha-trypsin inhibitor heavy chain 4
PAD
Online Access:http://link.springer.com/article/10.1186/s13075-018-1562-7

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