Early life course risk factors for childhood obesity: the IDEFICS case-control study.

BACKGROUND: The early life course is assumed to be a critical phase for childhood obesity; however the significance of single factors and their interplay is not well studied in childhood populations. OBJECTIVES: The investigation of pre-, peri- and postpartum risk factors on the risk of obesity at a...

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Main Authors: Karin Bammann, Jenny Peplies, Stefaan De Henauw, Monica Hunsberger, Denes Molnar, Luis A Moreno, Michael Tornaritis, Toomas Veidebaum, Wolfgang Ahrens, Alfonso Siani, IDEFICS Consortium
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3923715?pdf=render
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spelling doaj-20e8e82fbfa3474190d8662cdc97d0df2020-11-24T21:43:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0192e8691410.1371/journal.pone.0086914Early life course risk factors for childhood obesity: the IDEFICS case-control study.Karin BammannJenny PepliesStefaan De HenauwMonica HunsbergerDenes MolnarLuis A MorenoMichael TornaritisToomas VeidebaumWolfgang AhrensAlfonso SianiIDEFICS ConsortiumBACKGROUND: The early life course is assumed to be a critical phase for childhood obesity; however the significance of single factors and their interplay is not well studied in childhood populations. OBJECTIVES: The investigation of pre-, peri- and postpartum risk factors on the risk of obesity at age 2 to 9. METHODS: A case-control study with 1,024 1:1-matched case-control pairs was nested in the baseline survey (09/2007-05/2008) of the IDEFICS study, a population-based intervention study on childhood obesity carried out in 8 European countries in pre- and primary school settings. Conditional logistic regression was used for identification of risk factors. RESULTS: For many of the investigated risk factors, we found a raw effect in our study. In multivariate models, we could establish an effect for gestational weight gain (adjusted OR = 1.02; 95%CI 1.00-1.04), smoking during pregnancy (adjusted OR = 1.48; 95%CI 1.08-2.01), Caesarian section (adjusted OR = 1.38; 95%CI 1.10-1.74), and breastfeeding 4 to 11 months (adjusted OR = 0.77; 95%CI 0.62-0.96). Birth weight was related to lean mass rather than to fat mass, the effect of smoking was found only in boys, but not in girls. After additional adjustment for parental BMI and parental educational status, only gestational weight gain remained statistically significant. Both, maternal as well as paternal BMI were the strongest risk factors in our study, and they confounded several of the investigated associations. CONCLUSIONS: Key risk factors of childhood obesity in our study are parental BMI and gestational weight gain; consequently prevention approaches should target not only children but also adults. The monitoring of gestational weight seems to be of particular importance for early prevention of childhood obesity.http://europepmc.org/articles/PMC3923715?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Karin Bammann
Jenny Peplies
Stefaan De Henauw
Monica Hunsberger
Denes Molnar
Luis A Moreno
Michael Tornaritis
Toomas Veidebaum
Wolfgang Ahrens
Alfonso Siani
IDEFICS Consortium
spellingShingle Karin Bammann
Jenny Peplies
Stefaan De Henauw
Monica Hunsberger
Denes Molnar
Luis A Moreno
Michael Tornaritis
Toomas Veidebaum
Wolfgang Ahrens
Alfonso Siani
IDEFICS Consortium
Early life course risk factors for childhood obesity: the IDEFICS case-control study.
PLoS ONE
author_facet Karin Bammann
Jenny Peplies
Stefaan De Henauw
Monica Hunsberger
Denes Molnar
Luis A Moreno
Michael Tornaritis
Toomas Veidebaum
Wolfgang Ahrens
Alfonso Siani
IDEFICS Consortium
author_sort Karin Bammann
title Early life course risk factors for childhood obesity: the IDEFICS case-control study.
title_short Early life course risk factors for childhood obesity: the IDEFICS case-control study.
title_full Early life course risk factors for childhood obesity: the IDEFICS case-control study.
title_fullStr Early life course risk factors for childhood obesity: the IDEFICS case-control study.
title_full_unstemmed Early life course risk factors for childhood obesity: the IDEFICS case-control study.
title_sort early life course risk factors for childhood obesity: the idefics case-control study.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description BACKGROUND: The early life course is assumed to be a critical phase for childhood obesity; however the significance of single factors and their interplay is not well studied in childhood populations. OBJECTIVES: The investigation of pre-, peri- and postpartum risk factors on the risk of obesity at age 2 to 9. METHODS: A case-control study with 1,024 1:1-matched case-control pairs was nested in the baseline survey (09/2007-05/2008) of the IDEFICS study, a population-based intervention study on childhood obesity carried out in 8 European countries in pre- and primary school settings. Conditional logistic regression was used for identification of risk factors. RESULTS: For many of the investigated risk factors, we found a raw effect in our study. In multivariate models, we could establish an effect for gestational weight gain (adjusted OR = 1.02; 95%CI 1.00-1.04), smoking during pregnancy (adjusted OR = 1.48; 95%CI 1.08-2.01), Caesarian section (adjusted OR = 1.38; 95%CI 1.10-1.74), and breastfeeding 4 to 11 months (adjusted OR = 0.77; 95%CI 0.62-0.96). Birth weight was related to lean mass rather than to fat mass, the effect of smoking was found only in boys, but not in girls. After additional adjustment for parental BMI and parental educational status, only gestational weight gain remained statistically significant. Both, maternal as well as paternal BMI were the strongest risk factors in our study, and they confounded several of the investigated associations. CONCLUSIONS: Key risk factors of childhood obesity in our study are parental BMI and gestational weight gain; consequently prevention approaches should target not only children but also adults. The monitoring of gestational weight seems to be of particular importance for early prevention of childhood obesity.
url http://europepmc.org/articles/PMC3923715?pdf=render
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