Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient

Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient

47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human indu...

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Main Authors: Yuchang Chen, Zhanhui Ou, Bing Song, Yexing Xian, Shuming Ouyang, Yuhuan Xie, Yanting Xue, Xiaofang Sun
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117301034
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spelling doaj-20e441612fcb4ee8b138a67083984a962020-11-24T21:23:47ZengElsevierStem Cell Research1873-50611876-77532017-08-0123C576010.1016/j.scr.2017.06.002Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patientYuchang ChenZhanhui OuBing SongYexing XianShuming OuyangYuhuan XieYanting XueXiaofang Sun47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease.http://www.sciencedirect.com/science/article/pii/S1873506117301034
collection DOAJ
language English
format Article
sources DOAJ
author Yuchang Chen
Zhanhui Ou
Bing Song
Yexing Xian
Shuming Ouyang
Yuhuan Xie
Yanting Xue
Xiaofang Sun
spellingShingle Yuchang Chen
Zhanhui Ou
Bing Song
Yexing Xian
Shuming Ouyang
Yuhuan Xie
Yanting Xue
Xiaofang Sun
Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
Stem Cell Research
author_facet Yuchang Chen
Zhanhui Ou
Bing Song
Yexing Xian
Shuming Ouyang
Yuhuan Xie
Yanting Xue
Xiaofang Sun
author_sort Yuchang Chen
title Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
title_short Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
title_full Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
title_fullStr Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
title_full_unstemmed Generation of integration-free induced pluripotent stem cells (GZHMUi001-A) by reprogramming peripheral blood mononuclear cells from a 47, XXX syndrome patient
title_sort generation of integration-free induced pluripotent stem cells (gzhmui001-a) by reprogramming peripheral blood mononuclear cells from a 47, xxx syndrome patient
publisher Elsevier
series Stem Cell Research
issn 1873-5061
1876-7753
publishDate 2017-08-01
description 47, XXX syndrome is one of several sex-chromosomal aneuploidies, and it has an incidence of approximately 1/1000 in newborn females. Because of heterogeneity in X-inactivation, these patients may exhibit a variety of clinical symptoms. Here, we report the generation of an integration-free human induced pluripotent stem cell line (GZHMUi001-A) by using Sendai virus to reprogram peripheral blood mononuclear cells from a 47, XXX syndrome patient with premature ovarian failure. This 47, XXX iPS cell line has characteristics of pluripotent stem cells and is a useful tool for the investigation of this X chromosome aneuploid disease.
url http://www.sciencedirect.com/science/article/pii/S1873506117301034
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