POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS

POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS

The article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of pharmaceuticals. Their application is very import...

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Main Authors: A. V. Sosnov, S. V. Sadovnikov, F. M. Semchenko, K. A. Rufanov, V. N. Tohmahchi, A. A. Sosnova, I. A. Tyurin
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2019-01-01
Series:Разработка и регистрация лекарственных средств
Subjects:
severe and moderate pain
potent non-narcotic analgesic
lead compounds
biotargets of nervous system
ion channel blocker
tetrodotoxin
Online Access:https://www.pharmjournal.ru/jour/article/view/241
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spelling doaj-20e25fd954fa45c99e6f7c010cf1db9a2021-07-28T13:06:53ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0101196206241POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALSA. V. Sosnov0S. V. Sadovnikov1F. M. Semchenko2K. A. Rufanov3V. N. Tohmahchi4A. A. Sosnova5I. A. Tyurin6Federal S&T Center «Inversiya»; The Federal State Unitary Enterprise State Pharmaceutical Plant (FSUE «GosZMP»)Federal S&T Center «Inversiya»The Federal State Unitary Enterprise State Pharmaceutical Plant (FSUE «GosZMP»)The Federal State Unitary Enterprise State Pharmaceutical Plant (FSUE «GosZMP»)The Federal State Unitary Enterprise State Pharmaceutical Plant (FSUE «GosZMP»)The Federal State Unitary Enterprise State Pharmaceutical Plant (FSUE «GosZMP»)N.V. Sklifosovsky Research Institute of Emergency MedicineThe article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of pharmaceuticals. Their application is very important as an alternative to opiates. However, the actual number of drug candidates is very limited. As a result of the authors analysis one of the most potent non-narcotic analgesics (PNS neurons sodium channel blocker) - Tetrodotoxin (TTX) was recognized as the most promising. Currently FSUE «GosZMP» conducting preclinical studies of injectable preparation of TTX.https://www.pharmjournal.ru/jour/article/view/241severe and moderate painpotent non-narcotic analgesiclead compoundsbiotargets of nervous systemion channel blockertetrodotoxin
collection DOAJ
language Russian
format Article
sources DOAJ
author A. V. Sosnov
S. V. Sadovnikov
F. M. Semchenko
K. A. Rufanov
V. N. Tohmahchi
A. A. Sosnova
I. A. Tyurin
spellingShingle A. V. Sosnov
S. V. Sadovnikov
F. M. Semchenko
K. A. Rufanov
V. N. Tohmahchi
A. A. Sosnova
I. A. Tyurin
POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
Разработка и регистрация лекарственных средств
severe and moderate pain
potent non-narcotic analgesic
lead compounds
biotargets of nervous system
ion channel blocker
tetrodotoxin
author_facet A. V. Sosnov
S. V. Sadovnikov
F. M. Semchenko
K. A. Rufanov
V. N. Tohmahchi
A. A. Sosnova
I. A. Tyurin
author_sort A. V. Sosnov
title POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
title_short POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
title_full POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
title_fullStr POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
title_full_unstemmed POTENT NON-NARCOTIC ANALGESICS AS А DIRECTION IN DEVELOPMENT OF PHARMACEUTICALS
title_sort potent non-narcotic analgesics as а direction in development of pharmaceuticals
publisher LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
series Разработка и регистрация лекарственных средств
issn 2305-2066
2658-5049
publishDate 2019-01-01
description The article describes some approaches to choice of the most potent non-narcotic analgesics among agents investigated in various R&D stages. Preparations non-narcotic analgesics for relief of severe and moderate pain are relatively new area of pharmaceuticals. Their application is very important as an alternative to opiates. However, the actual number of drug candidates is very limited. As a result of the authors analysis one of the most potent non-narcotic analgesics (PNS neurons sodium channel blocker) - Tetrodotoxin (TTX) was recognized as the most promising. Currently FSUE «GosZMP» conducting preclinical studies of injectable preparation of TTX.
topic severe and moderate pain
potent non-narcotic analgesic
lead compounds
biotargets of nervous system
ion channel blocker
tetrodotoxin
url https://www.pharmjournal.ru/jour/article/view/241
work_keys_str_mv AT avsosnov potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
AT svsadovnikov potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
AT fmsemchenko potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
AT karufanov potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
AT vntohmahchi potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
AT aasosnova potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
AT iatyurin potentnonnarcoticanalgesicsasadirectionindevelopmentofpharmaceuticals
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