Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding[S]

Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding[S]

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. We have previously shown that, in addition to the epidermal growth factor precursor homology repeat-A of LDLR, at least...

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Bibliographic Details
Main Authors: Shi-jun Deng, Adekunle Alabi, Hong-mei Gu, Ayinuer Adijiang, Shucun Qin, Da-wei Zhang
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Journal of Lipid Research
Subjects:
LDL binding
hypercholesterolemia
atherosclerosis
site-directed mutagenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520326158

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