Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro

During inflammation, activated leukocytes release cytotoxic mediators that compromise blood–brain barrier (BBB) function. Under inflammatory conditions, myeloperoxidase (MPO) is critically involved in inflicting BBB damage. We used genetic and pharmacological approaches to investigate whether MPO in...

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Bibliographic Details
Main Authors: Madeleine Goeritzer, Eva Bernhart, Ioanna Plastira, Helga Reicher, Christina Leopold, Thomas O. Eichmann, Gerald Rechberger, Corina T. Madreiter-Sokolowski, Jürgen Prasch, Philipp Eller, Wolfgang F. Graier, Dagmar Kratky, Ernst Malle, Wolfgang Sattler
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
blood–brain barrier
calorimetry
ceramides
cytokines
fatty acid
mitochondrial function
myeloperoxidase
sphingomyelins
Online Access:https://www.mdpi.com/1422-0067/21/3/1143

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https://www.mdpi.com/1422-0067/21/3/1143

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