RNA-Seq Analyses Reveal That Endothelial Activation and Fibrosis Are Induced Early and Progressively by Besnoitia besnoiti Host Cell Invasion and Proliferation

RNA-Seq Analyses Reveal That Endothelial Activation and Fibrosis Are Induced Early and Progressively by Besnoitia besnoiti Host Cell Invasion and Proliferation

The pathogenesis of bovine besnoitiosis and the molecular bases that govern disease progression remain to be elucidated. Thus, we have employed an in vitro model of infection based on primary bovine aortic endothelial cells (BAEC), target cells during the acute infection. Host-parasite interactions...

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Bibliographic Details
Main Authors: Alejandro Jiménez-Meléndez, Chandra Ramakrishnan, Adrian B. Hehl, Giancarlo Russo, Gema Álvarez-García
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Besnoitia besnoiti
tachyzoite
primary bovine aorta endothelial cells (BAEC)
transcriptome
RNA-Seq
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00218/full

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