Obesity and reproductive function of women: epigenetic and somato-psychological features

• Main Authors: Elena N. Andreeva, Yulia S. Absatarova, Ekaterina V. Sheremetyeva, Valentina A. Fursenko
• Format: Article
• Language: English
• Published: Endocrinology Research Centre 2019-09-01
• Series: Ожирение и метаболизм
• Subjects: obesity; overweight; polycystic ovary syndrome; gestational diabetes; epigenetics; intrauterine programming; ovarian dysfunction
• Online Access: https://omet-endojournals.ru/omet/article/viewFile/10113/7611

The review article presents data on the effects of obesity on the female reproductive system and offspring of mothers with overweight or obesity, such as infertility, miscarriages, premature birth, stillbirth, congenital anomalies and prematurity, as well as a high risk of cesarean section. Obesity accompanies polycystic ovary syndrome, worsening the metabolic profile and increasing the risk of developing depression and eating disorders. Maternal obesity and hyperglycemia are able to influence the formation of the fetus by epigenetic mechanisms without affecting the nucleotide sequences. Subsequently, the metabolic and cardiovascular risks increase in the descendants of obese or overweight mothers and gestational diabetes. Patients with obesity are characterized by a folic acid deficiency and a deficiency of the luteal phase. Exogenous administration of these substances improves pregnancy outcomes and prevents congenital malformations.