25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome
The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates neuroinflammation via activating the NLRP3 inflammasome.
Bibliographic Details
| Main Authors: |
Jiho Jang,
Sangjun Park,
Hye Jin Hur,
Hyun-Ju Cho,
Inhwa Hwang,
Yun Pyo Kang,
Isak Im,
Hyunji Lee,
Eunju Lee,
Wonsuk Yang,
Hoon-Chul Kang,
Sung Won Kwon,
Je-Wook Yu,
Dong-Wook Kim |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13129
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