The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized...

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Bibliographic Details
Main Authors: Masahiro Ariga, Yasuo Tohda, Kazushige Hori, Mina Tamura, Nagatoshi Nishiwaki
Format: Article
Language:English
Published: MDPI AG 2003-06-01
Series:Molecules
Subjects:
Nitropyrimidinone
ring transformation
pyridone
pyrimidine
aminopyridine
Online Access:http://www.mdpi.com/1420-3049/8/6/500/
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spelling doaj-20c63d3908b443f0a22546adcc8db9412020-11-24T20:43:22ZengMDPI AGMolecules1420-30492003-06-018650050410.3390/80600500The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-oneMasahiro ArigaYasuo TohdaKazushige HoriMina TamuraNagatoshi Nishiwaki3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.http://www.mdpi.com/1420-3049/8/6/500/Nitropyrimidinonering transformationpyridonepyrimidineaminopyridine
collection DOAJ
language English
format Article
sources DOAJ
author Masahiro Ariga
Yasuo Tohda
Kazushige Hori
Mina Tamura
Nagatoshi Nishiwaki
spellingShingle Masahiro Ariga
Yasuo Tohda
Kazushige Hori
Mina Tamura
Nagatoshi Nishiwaki
The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
Molecules
Nitropyrimidinone
ring transformation
pyridone
pyrimidine
aminopyridine
author_facet Masahiro Ariga
Yasuo Tohda
Kazushige Hori
Mina Tamura
Nagatoshi Nishiwaki
author_sort Masahiro Ariga
title The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_short The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_full The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_fullStr The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_full_unstemmed The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one
title_sort ring transformation of 3-methyl-5-nitropyrimidin-4(3h)-one
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2003-06-01
description 3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.
topic Nitropyrimidinone
ring transformation
pyridone
pyrimidine
aminopyridine
url http://www.mdpi.com/1420-3049/8/6/500/
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