The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized...

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Bibliographic Details
Main Authors: Masahiro Ariga, Yasuo Tohda, Kazushige Hori, Mina Tamura, Nagatoshi Nishiwaki
Format: Article
Language:English
Published: MDPI AG 2003-06-01
Series:Molecules
Subjects:
Nitropyrimidinone
ring transformation
pyridone
pyrimidine
aminopyridine
Online Access:http://www.mdpi.com/1420-3049/8/6/500/
Description
Summary:3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.
ISSN:1420-3049

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