The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions

The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions

Drug-induced liver injury (DILI) with extrahepatic adverse drug reaction (EHADR) is the injury of extrahepatic organs which is caused by the same drug inducing liver injury and may occur simultaneously or successively with DILI, such as the skin, gastrointestinal tract, blood system, cardiovascular...

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Main Author: HOU Junxing
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2020-03-01
Series:Linchuang Gandanbing Zazhi
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=10600
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spelling doaj-20c582d9cf8e4070800a28efddf502a02020-11-25T03:15:25ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562020-03-01363497500The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactionsHOU Junxing0Bayi Hospital Affiliated to Nanjing University of Chinese MedicineDrug-induced liver injury (DILI) with extrahepatic adverse drug reaction (EHADR) is the injury of extrahepatic organs which is caused by the same drug inducing liver injury and may occur simultaneously or successively with DILI, such as the skin, gastrointestinal tract, blood system, cardiovascular system, and bone and joint system, and it should be taken seriously in clinical practice. DILI with EHADR is not rare, and its pathogenesis may be associated with various factors including the physicochemical properties, distribution, metabolism, excretion, biological activity, and immunological properties of drugs, host genetic background, and underlying diseases. The diagnosis and treatment of DILI with EHADR is more challenging than that of DILI alone.http://www.lcgdbzz.org/qk_content.asp?id=10600
collection DOAJ
language zho
format Article
sources DOAJ
author HOU Junxing
spellingShingle HOU Junxing
The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
Linchuang Gandanbing Zazhi
author_facet HOU Junxing
author_sort HOU Junxing
title The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
title_short The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
title_full The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
title_fullStr The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
title_full_unstemmed The pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
title_sort pathogenesis, diagnosis, and treatment of drug-induced liver injury with extrahepatic adverse drug reactions
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2020-03-01
description Drug-induced liver injury (DILI) with extrahepatic adverse drug reaction (EHADR) is the injury of extrahepatic organs which is caused by the same drug inducing liver injury and may occur simultaneously or successively with DILI, such as the skin, gastrointestinal tract, blood system, cardiovascular system, and bone and joint system, and it should be taken seriously in clinical practice. DILI with EHADR is not rare, and its pathogenesis may be associated with various factors including the physicochemical properties, distribution, metabolism, excretion, biological activity, and immunological properties of drugs, host genetic background, and underlying diseases. The diagnosis and treatment of DILI with EHADR is more challenging than that of DILI alone.
url http://www.lcgdbzz.org/qk_content.asp?id=10600
work_keys_str_mv AT houjunxing thepathogenesisdiagnosisandtreatmentofdruginducedliverinjurywithextrahepaticadversedrugreactions
AT houjunxing pathogenesisdiagnosisandtreatmentofdruginducedliverinjurywithextrahepaticadversedrugreactions
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