Posttranslational Modifications of Smurfs: Emerging Regulation in Cancer

Posttranslational Modifications of Smurfs: Emerging Regulation in Cancer

Smad ubiquitination regulatory factors (Smurfs) belong to the Nedd4 subfamily of HECT-type E3 ubiquitin ligases. Under normal situations, Smurfs are exactly managed by upstream regulators, and thereby strictly control tumor biological processes, including cell growth, differentiation, apoptosis, pol...

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Bibliographic Details
Main Authors: Longtao Yang, Wenwen Zhou, Hui Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
Smurfs
posttranslational modification (PTM)
cancer
phosphorylation
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.610663/full

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