Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel...

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Bibliographic Details
Main Authors: Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05877-z

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