Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution

Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel...

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Main Authors: Takayoshi Awakawa, Takuma Fujioka, Lihan Zhang, Shotaro Hoshino, Zhijuan Hu, Junko Hashimoto, Ikuko Kozone, Haruo Ikeda, Kazuo Shin-Ya, Wen Liu, Ikuro Abe
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05877-z
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spelling doaj-209bc4d1b5344a32b292f405caa6ac8b2021-05-11T10:29:02ZengNature Publishing GroupNature Communications2041-17232018-08-019111010.1038/s41467-018-05877-zReprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolutionTakayoshi Awakawa0Takuma Fujioka1Lihan Zhang2Shotaro Hoshino3Zhijuan Hu4Junko Hashimoto5Ikuko Kozone6Haruo Ikeda7Kazuo Shin-Ya8Wen Liu9Ikuro Abe10Graduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoGraduate School of Pharmaceutical Sciences, The University of TokyoJapan Biological Informatics ConsortiumJapan Biological Informatics ConsortiumLaboratory of Microbial Engineering, Kitasato Institute for Life Sciences, Kitasato UniversityCollaborative Research Institute for Innovative Microbiology, The University of TokyoState Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesGraduate School of Pharmaceutical Sciences, The University of TokyoModifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones.https://doi.org/10.1038/s41467-018-05877-z
collection DOAJ
language English
format Article
sources DOAJ
author Takayoshi Awakawa
Takuma Fujioka
Lihan Zhang
Shotaro Hoshino
Zhijuan Hu
Junko Hashimoto
Ikuko Kozone
Haruo Ikeda
Kazuo Shin-Ya
Wen Liu
Ikuro Abe
spellingShingle Takayoshi Awakawa
Takuma Fujioka
Lihan Zhang
Shotaro Hoshino
Zhijuan Hu
Junko Hashimoto
Ikuko Kozone
Haruo Ikeda
Kazuo Shin-Ya
Wen Liu
Ikuro Abe
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Nature Communications
author_facet Takayoshi Awakawa
Takuma Fujioka
Lihan Zhang
Shotaro Hoshino
Zhijuan Hu
Junko Hashimoto
Ikuko Kozone
Haruo Ikeda
Kazuo Shin-Ya
Wen Liu
Ikuro Abe
author_sort Takayoshi Awakawa
title Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_short Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_full Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_fullStr Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_full_unstemmed Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
title_sort reprogramming of the antimycin nrps-pks assembly lines inspired by gene evolution
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Modifying the non-ribosomal peptide synthase (NRPS)/polyketide synthase (PKS) pathway to generate novel non-ribosomal peptides often results in a loss of productivity. Here the authors use evolutionary alignments of NRPS/PKS gene clusters to guide rational design of complexes that can produce novel lactones.
url https://doi.org/10.1038/s41467-018-05877-z
work_keys_str_mv AT takayoshiawakawa reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT takumafujioka reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT lihanzhang reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT shotarohoshino reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT zhijuanhu reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
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AT ikukokozone reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT haruoikeda reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT kazuoshinya reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT wenliu reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
AT ikuroabe reprogrammingoftheantimycinnrpspksassemblylinesinspiredbygeneevolution
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