Engineered <i>Lactococcus lactis</i> Secreting IL-23 Receptor-Targeted REX Protein Blockers for Modulation of IL-23/Th17-Mediated Inflammation

Engineered <i>Lactococcus lactis</i> Secreting IL-23 Receptor-Targeted REX Protein Blockers for Modulation of IL-23/Th17-Mediated Inflammation

<i>Lactococcus lactis</i>, a probiotic bacterium of food origin, has recently been demonstrated as a suitable strain for the production and in vivo delivery of therapeutically important proteins into the gut. We aimed to engineer recombinant <i>L. lactis</i> cells producing/s...

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Bibliographic Details
Main Authors: Tina Vida Plavec, Milan Kuchař, Anja Benko, Veronika Lišková, Jiří Černý, Aleš Berlec, Petr Malý
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Microorganisms
Subjects:
lactococcus
binding protein
albumin-binding domain
IL-23 cytokine
IL-23R
surface display
Online Access:https://www.mdpi.com/2076-2607/7/5/152

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