Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is Fc𝛾RIIB Dependent

Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is Fc𝛾RIIB Dependent

We showed earlier that experimental autoimmune encephalomyelitis (EAE) in human C-reactive protein (CRP) transgenic mice (CRPtg) has delayed onset and reduced severity compared to wild-type mice. Since human CRP is known to engage Fc receptors and Fc receptors are known to play a role in EAE in the...

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Bibliographic Details
Main Authors:	Xian-Zhen Hu, Tyler T. Wright, Nicholas R. Jones, Theresa N. Ramos, Gregory A. Skibinski, Mark A. McCrory, Scott R. Barnum, Alexander J. Szalai
Format:	Article
Language:	English
Published:	Hindawi Limited 2011-01-01
Series:	Autoimmune Diseases
Online Access:	http://dx.doi.org/10.4061/2011/484936

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