The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

<b>Objective</b> To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether the underlying metabolic and immunological mechanism is associated with ROS/eIF2B and natural killer (NK) cells. <b>Methods</b> We employed TWS119 to inactivate GSK-3β by phosphor...

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Bibliographic Details
Main Authors: Fengjiao Jin, Zhaozhen Wu, Xiao Hu, Jiahui Zhang, Zihe Gao, Xiao Han, Junfang Qin, Chen Li, Yue Wang
Format: Article
Language:English
Published: China Anti-Cancer Association 2019-03-01
Series:Cancer Biology & Medicine
Subjects:
GSK-3β
NK cells
NKG2D/NKG2DLs
ROS
eIF2B
breast cancer
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1367

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/1367

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