1-(4-Hexylbenzoyl)-3-methylthiourea

The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass...

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Main Authors:	Ruswanto Ruswanto, Richa Mardianingrum, Tresna Lestari, Tita Nofianti, Siswandono Siswandono
Format:	Article
Language:	English
Published:	MDPI AG 2018-07-01
Series:	Molbank
Subjects:	acylation reaction cancer spectrophotometry thiourea
Online Access:	http://www.mdpi.com/1422-8599/2018/3/M1005

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spelling	doaj-208f193c1c4d4eea909357c26ef7be4c2020-11-24T22:29:14ZengMDPI AGMolbank1422-85992018-07-0120183M100510.3390/M1005M10051-(4-Hexylbenzoyl)-3-methylthioureaRuswanto Ruswanto0Richa Mardianingrum1Tresna Lestari2Tita Nofianti3Siswandono Siswandono4Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Bakti Tunas Husada, Jl. Cilolohan No. 36, Tasikmalaya 46115, IndonesiaDepartment of Pharmacy, Universitas Perjuangan, Jl. Pembela Tanah Air 177, Tasikmalaya 46115, IndonesiaDepartment of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Bakti Tunas Husada, Jl. Cilolohan No. 36, Tasikmalaya 46115, IndonesiaDepartment of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Bakti Tunas Husada, Jl. Cilolohan No. 36, Tasikmalaya 46115, IndonesiaFaculty of Pharmacy, Airlangga University, Jl. Darmawangsa Dalam 4-6, Surabaya 60286, IndonesiaThe 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D, WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea.http://www.mdpi.com/1422-8599/2018/3/M1005acylation reactioncancerspectrophotometrythiourea
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ruswanto Ruswanto Richa Mardianingrum Tresna Lestari Tita Nofianti Siswandono Siswandono
spellingShingle	Ruswanto Ruswanto Richa Mardianingrum Tresna Lestari Tita Nofianti Siswandono Siswandono 1-(4-Hexylbenzoyl)-3-methylthiourea Molbank acylation reaction cancer spectrophotometry thiourea
author_facet	Ruswanto Ruswanto Richa Mardianingrum Tresna Lestari Tita Nofianti Siswandono Siswandono
author_sort	Ruswanto Ruswanto
title	1-(4-Hexylbenzoyl)-3-methylthiourea
title_short	1-(4-Hexylbenzoyl)-3-methylthiourea
title_full	1-(4-Hexylbenzoyl)-3-methylthiourea
title_fullStr	1-(4-Hexylbenzoyl)-3-methylthiourea
title_full_unstemmed	1-(4-Hexylbenzoyl)-3-methylthiourea
title_sort	1-(4-hexylbenzoyl)-3-methylthiourea
publisher	MDPI AG
series	Molbank
issn	1422-8599
publishDate	2018-07-01
description	The 1-(4-hexylbenzoyl)-3-methylthiourea compound has been successfully synthesized by reacting 4-hexylbenzoyl chloride and 1-methylthiourea via the reflux method using a triethylamine catalyst. The 1-(4-hexylbenzoyl)-3-methylthiourea compound was identified by UV-visible, FT-IR, 13C/1H-NMR and Mass spectrophotometry. From the activity test on four cancer cell lines (HeLa, T47D, WiDr and MCF7 cell), it could be seen that it had better activity on four cancer cells than the control, hydroxyurea.
topic	acylation reaction cancer spectrophotometry thiourea
url	http://www.mdpi.com/1422-8599/2018/3/M1005
work_keys_str_mv	AT ruswantoruswanto 14hexylbenzoyl3methylthiourea AT richamardianingrum 14hexylbenzoyl3methylthiourea AT tresnalestari 14hexylbenzoyl3methylthiourea AT titanofianti 14hexylbenzoyl3methylthiourea AT siswandonosiswandono 14hexylbenzoyl3methylthiourea
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1-(4-Hexylbenzoyl)-3-methylthiourea

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