Sequential Parameter Estimation for Mammalian Cell Model Based on In Silico Design of Experiments

Sequential Parameter Estimation for Mammalian Cell Model Based on In Silico Design of Experiments

Due to the complicated metabolism of mammalian cells, the corresponding dynamic mathematical models usually consist of large sets of differential and algebraic equations with a large number of parameters to be estimated. On the other hand, the measured data for estimating the model parameters are li...

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Bibliographic Details
Main Authors: Zhenyu Wang, Hana Sheikh, Kyongbum Lee, Christos Georgakis
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Processes
Subjects:
Pharmaceutical Processes
Mammalian Cell Culture
sensitivity analysis
parameter estimation
Design of Experiments
Online Access:http://www.mdpi.com/2227-9717/6/8/100

Internet

http://www.mdpi.com/2227-9717/6/8/100

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