Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and mucosally, respectively, has previously been sugges...

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Bibliographic Details
Main Authors: Aneesh Thakur, Fernanda Endringer Pinto, Harald Severin Hansen, Peter Andersen, Dennis Christensen, Christian Janfelt, Camilla Foged
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
H56/CAF01
tuberculosis
subunit vaccine
pulmonary administration
myeloid cells
antigen-presenting cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00803/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00803/full

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