Transient Decrease of Circulating and Tissular Dendritic Cells in Patients With Mycobacterial Disease and With Partial Dominant IFNγR1 Deficiency

Transient Decrease of Circulating and Tissular Dendritic Cells in Patients With Mycobacterial Disease and With Partial Dominant IFNγR1 Deficiency

Interferon-γ receptor 1 (IFNγR1) deficiency is one of the inborn errors of IFN-γ immunity underlying Mendelian Susceptibility to Mycobacterial Disease (MSMD). This molecular circuit plays a crucial role in regulating the interaction between dendritic cells (DCs) and T lymphocytes, thus affecting DCs...

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Bibliographic Details
Main Authors: Laura Dotta, Donatella Vairo, Mauro Giacomelli, Daniele Moratto, Nicola Tamassia, William Vermi, Silvia Lonardi, Jean-Laurent Casanova, Jacinta Bustamante, Silvia Giliani, Raffaele Badolato
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
partial IFNγR1 deficiency
IFNγ
dendritic cells deficiency
mycobacteria
MSMD
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01161/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01161/full

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