IL1B - 511 gene polymorphism (rs16944) in Brazilian patients diagnosed with haemorrhagic stroke

• Main Authors: Gilson Luiz de Carvalho Lopes Filho, Aline Ribeiro Barros, Helia Carla Souza, Daniel Oliveira Freire, Luzitano Brandão Ferreira, Izabel Cristina Rodrigues da Silva
• Format: Article
• Language: Portuguese
• Published: Faculdade de Ciências e Educação Sena Aires 2019-12-01
• Series: REVISA
• Subjects: interleucina-1; aveh; polimorfismo genético.
• Online Access: http://revistafacesa.senaaires.com.br/index.php/revisa/article/view/468
• ISSN: 2316-848X; 2179-0981

<p><strong>Objective: </strong>To assess the possible relationship between IL1B (-511 C / T) polymorphism and the prognosis of HS. <strong>Method:</strong> To evaluate this questioning, we used a sample of 81 individuals diagnosed with HS, who underwent analysis of the IL1B-511 C / T polymorphism by the PCR-RFLP technique. Statistical analysis adopted a significance level of 5%. <strong>Results:</strong> Research has shown that the presence of CC or CT / TT genotypes does not result in a statistical association between IL1B polymorphism and the appearance of HS (P = 0.174). <strong>Conclusion:</strong> The study demonstrated that C and T variation in rs16944 gene polymorphism is not associated with the selected clinical aspects. It also showed no statistical association with disease manifestation and genotypic variation.</p>