Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media

Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media

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The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II)  and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand rati...

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Main Authors: Ramesh Ware, D. B. Jirekar, P. P. Ghumare, Shailendrasingh Thakur
Format: Article
Language:English
Published: PURKH 2020-06-01
Series:To Chemistry Journal
Subjects:
pH metry
Efavirenz
transition metal
alkaline earth metal
Stability Constant
Online Access:https://purkh.com/index.php/tochem/article/view/769
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spelling doaj-20670ea5ec534e33a982a726ef9c50092020-11-25T01:53:22ZengPURKHTo Chemistry Journal2581-75072020-06-016Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media Ramesh Ware0D. B. Jirekar1P. P. Ghumare2Shailendrasingh Thakur3Milliya College, Beed. (India)Anandrao Dhonde College, Kada, Dist. Beed. (India)Anandrao Dhonde College, Kada, Dist. Beed. (India)Milliya College, Beed. (India) The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II)  and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio = 1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constants (log K) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as:                                                        Fe3+ > Cu2+ > Mg2+ > Ca2+     https://purkh.com/index.php/tochem/article/view/769pH metryEfavirenz transition metalalkaline earth metalStability Constant
collection DOAJ
language English
format Article
sources DOAJ
author Ramesh Ware
D. B. Jirekar
P. P. Ghumare
Shailendrasingh Thakur
spellingShingle Ramesh Ware
D. B. Jirekar
P. P. Ghumare
Shailendrasingh Thakur
Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
To Chemistry Journal
pH metry
Efavirenz
transition metal
alkaline earth metal
Stability Constant
author_facet Ramesh Ware
D. B. Jirekar
P. P. Ghumare
Shailendrasingh Thakur
author_sort Ramesh Ware
title Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
title_short Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
title_full Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
title_fullStr Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
title_full_unstemmed Formation of Alkaline Earth and Transition Metal Complexes with Efavirenz Drug in Ethanol-Water Media
title_sort formation of alkaline earth and transition metal complexes with efavirenz drug in ethanol-water media
publisher PURKH
series To Chemistry Journal
issn 2581-7507
publishDate 2020-06-01
description The stability constant of Efavirenz drug with alkaline earth metal ions Mg(II), Ca(II)  and transition metal ions Fe(III), Cu(II) were investigate using pH metric titration technique in 20%(v/v) ethanol-water mixture at 27 °C temperature and at an ionic strength of 0.1M NaClO4.{Metal to ligand ratio = 1:5 & 1:1}The method of Calvin and Bjerrum as adopted by Irving and Rossotti has been employed to determine proton ligand (pKa) and metal-ligand stability constants (log K) values. It is observed that alkaline earth metal & transition metal ion forms 1:1 and 1:2 complexes. The order of stability constants for these metal complexes was as:                                                        Fe3+ > Cu2+ > Mg2+ > Ca2+    
topic pH metry
Efavirenz
transition metal
alkaline earth metal
Stability Constant
url https://purkh.com/index.php/tochem/article/view/769
work_keys_str_mv AT rameshware formationofalkalineearthandtransitionmetalcomplexeswithefavirenzdruginethanolwatermedia
AT dbjirekar formationofalkalineearthandtransitionmetalcomplexeswithefavirenzdruginethanolwatermedia
AT ppghumare formationofalkalineearthandtransitionmetalcomplexeswithefavirenzdruginethanolwatermedia
AT shailendrasinghthakur formationofalkalineearthandtransitionmetalcomplexeswithefavirenzdruginethanolwatermedia
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