Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis

Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis

The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma...

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Main Authors: Lars Fredriksson, Per Alstergren, Sigvard Kopp
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/MI.2005.194
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spelling doaj-2051aa53822246c0aea35174b0dee88e2020-11-24T23:52:42ZengHindawi LimitedMediators of Inflammation0962-93511466-18612005-01-012005419420110.1155/MI.2005.194Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ ArthritisLars Fredriksson0Per Alstergren1Sigvard Kopp2Department of Clinical Oral Physiology, Institute of Odontology, Karolinska Institute, Box 4604, Huddinge, 141 04, SwedenDepartment of Clinical Oral Physiology, Institute of Odontology, Karolinska Institute, Box 4604, Huddinge, 141 04, SwedenDepartment of Clinical Oral Physiology, Institute of Odontology, Karolinska Institute, Box 4604, Huddinge, 141 04, SwedenThe aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.http://dx.doi.org/10.1155/MI.2005.194
collection DOAJ
language English
format Article
sources DOAJ
author Lars Fredriksson
Per Alstergren
Sigvard Kopp
spellingShingle Lars Fredriksson
Per Alstergren
Sigvard Kopp
Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
Mediators of Inflammation
author_facet Lars Fredriksson
Per Alstergren
Sigvard Kopp
author_sort Lars Fredriksson
title Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_short Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_full Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_fullStr Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_full_unstemmed Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
title_sort serotonergic mechanisms influence the response to glucocorticoid treatment in tmj arthritis
publisher Hindawi Limited
series Mediators of Inflammation
issn 0962-9351
1466-1861
publishDate 2005-01-01
description The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.
url http://dx.doi.org/10.1155/MI.2005.194
work_keys_str_mv AT larsfredriksson serotonergicmechanismsinfluencetheresponsetoglucocorticoidtreatmentintmjarthritis
AT peralstergren serotonergicmechanismsinfluencetheresponsetoglucocorticoidtreatmentintmjarthritis
AT sigvardkopp serotonergicmechanismsinfluencetheresponsetoglucocorticoidtreatmentintmjarthritis
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