Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives
The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identificatio...
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MDPI AG
2011-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/2/1825/ |
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doaj-2050e87cb57f43e0a0c4e4e27d9208f32020-11-24T22:59:35ZengMDPI AGMolecules1420-30492011-02-011621825183310.3390/molecules16021825Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic DerivativesWilson R. CunhaAdemar A. da Silva FilhoSérgio AlbuquerqueFransérgio F. dos SantosLizandra G. MagalhãesMilton GroppoAna H. JanuárioRodrigo Cassio Sola VenezianiValéria M. M. GimenezJuliana A. PeixotoAntônio E. M. CrottiMárcio Luis Andrade e SilvaThe in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity. http://www.mdpi.com/1420-3049/16/2/1825/antileishmanial activityMiconia langsdorffiioleanolic acidursolic acid |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Wilson R. Cunha Ademar A. da Silva Filho Sérgio Albuquerque Fransérgio F. dos Santos Lizandra G. Magalhães Milton Groppo Ana H. Januário Rodrigo Cassio Sola Veneziani Valéria M. M. Gimenez Juliana A. Peixoto Antônio E. M. Crotti Márcio Luis Andrade e Silva |
| spellingShingle |
Wilson R. Cunha Ademar A. da Silva Filho Sérgio Albuquerque Fransérgio F. dos Santos Lizandra G. Magalhães Milton Groppo Ana H. Januário Rodrigo Cassio Sola Veneziani Valéria M. M. Gimenez Juliana A. Peixoto Antônio E. M. Crotti Márcio Luis Andrade e Silva Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives Molecules antileishmanial activity Miconia langsdorffii oleanolic acid ursolic acid |
| author_facet |
Wilson R. Cunha Ademar A. da Silva Filho Sérgio Albuquerque Fransérgio F. dos Santos Lizandra G. Magalhães Milton Groppo Ana H. Januário Rodrigo Cassio Sola Veneziani Valéria M. M. Gimenez Juliana A. Peixoto Antônio E. M. Crotti Márcio Luis Andrade e Silva |
| author_sort |
Wilson R. Cunha |
| title |
Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives |
| title_short |
Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives |
| title_full |
Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives |
| title_fullStr |
Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives |
| title_full_unstemmed |
Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives |
| title_sort |
antileishmanial activity of the hydroalcoholic extract of miconia langsdorffii, isolated compounds, and semi-synthetic derivatives |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2011-02-01 |
| description |
The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity. |
| topic |
antileishmanial activity Miconia langsdorffii oleanolic acid ursolic acid |
| url |
http://www.mdpi.com/1420-3049/16/2/1825/ |
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