Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection

Abstract Background We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environment that activates canonical Wnt/β-catenin signaling. The localizati...

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Bibliographic Details
Main Authors: R. Betten, B. Scharner, S. Probst, B. Edemir, N. A. Wolff, C. Langelueddecke, W.-K. Lee, F. Thévenod
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
Kidney
hypertonicity
osmotic stress
cell death
proliferation
lipocalin-2
Online Access:http://link.springer.com/article/10.1186/s12964-018-0285-3

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