Comparison of Two Transmission Electron Microscopy Methods to Visualize Drug-Induced Alterations of Gram-Negative Bacterial Morphology

Comparison of Two Transmission Electron Microscopy Methods to Visualize Drug-Induced Alterations of Gram-Negative Bacterial Morphology

In this study, we optimized and compared different transmission electron microscopy (TEM) methods to visualize changes to Gram-negative bacterial morphology induced by treatment with a robenidine analogue (NCL195) and colistin combination. Aldehyde-fixed bacterial cells (untreated, treated with coli...

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Bibliographic Details
Main Authors: Hang Thi Nguyen, Lisa A. O’Donovan, Henrietta Venter, Cecilia C. Russell, Adam McCluskey, Stephen W. Page, Darren J. Trott, Abiodun D. Ogunniyi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antibiotics
Subjects:
transmission electron microscopy
bacterial cell wall
bacterial membrane
Gram-negative bacteria
colistin
drug interaction
Online Access:https://www.mdpi.com/2079-6382/10/3/307

Internet

https://www.mdpi.com/2079-6382/10/3/307

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