Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy

Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy

Abstract Background Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP, ADIPOQ, RETN) play key roles in the pathophysiology of T2DM. We hyp...

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Bibliographic Details
Main Authors: Azadeh Houshmand-Oeregaard, Ninna S. Hansen, Line Hjort, Louise Kelstrup, Christa Broholm, Elisabeth R. Mathiesen, Tine D. Clausen, Peter Damm, Allan Vaag
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Clinical Epigenetics
Subjects:
Epigenetics
Methylation
Diabetes
Pregnancy
Gestational diabetes
Fetal programming
Online Access:http://link.springer.com/article/10.1186/s13148-017-0338-2

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