Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells

Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells

The data provides information in support of the research article Moraes et al., Atherosclerosis 243(2) (2015) 477–485 [1]. Here we provide data behind the mechanisms involved in Angiotensin II (Ang II) effects on vascular smooth muscle cells (VSMC). Ang II-induced VSMC ROS production is modulated by...

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Main Authors: João Alfredo Moraes, Ana Clara Frony, Aline Maria Dias, Mariana Renovato-Martins, Genilson Rodrigues, Cezary Marcinkiewicz, Jamil Assreuy, Christina Barja-Fidalgo
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340915003480
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spelling doaj-203ae3c8f7df4f8a852327a860a9e0462020-11-25T02:36:42ZengElsevierData in Brief2352-34092016-03-016330340Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cellsJoão Alfredo Moraes0Ana Clara Frony1Aline Maria Dias2Mariana Renovato-Martins3Genilson Rodrigues4Cezary Marcinkiewicz5Jamil Assreuy6Christina Barja-Fidalgo7Laboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, BrazilLaboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, BrazilLaboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, BrazilLaboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, BrazilLaboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, BrazilDepartment of Bioengineering, College of Engineering, Temple University, Philadelphia, PA, USADepartment of Pharmacology, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, BrazilLaboratory of Cellular and Molecular Pharmacology, Department of Cell Biology, IBRAG, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil; Corresponding author.The data provides information in support of the research article Moraes et al., Atherosclerosis 243(2) (2015) 477–485 [1]. Here we provide data behind the mechanisms involved in Angiotensin II (Ang II) effects on vascular smooth muscle cells (VSMC). Ang II-induced VSMC ROS production is modulated by alpha1beta1 integrin. Ang II also stimulates ROS production in VSMC via p47phox, a NOX2 subunit. Furthermore, Ang II effect on VSMC migration was also inhibited by NOX2 inhibitor. We showed that obtustatin, alpha1beta1 integrin blocker, inhibited Ang II effect on p47phox activation. Ang II effect on ROS production is also PI3K dependent. Finally we showed that NOX1 and Integrin-Linked-Kinase (ILK) are crucial to NOX2 activation. The research provides information about the sequential events of NOX1/alpha1beta1 integrin/ILK/NOX2 in Ang II effects on VSMC.http://www.sciencedirect.com/science/article/pii/S2352340915003480
collection DOAJ
language English
format Article
sources DOAJ
author João Alfredo Moraes
Ana Clara Frony
Aline Maria Dias
Mariana Renovato-Martins
Genilson Rodrigues
Cezary Marcinkiewicz
Jamil Assreuy
Christina Barja-Fidalgo
spellingShingle João Alfredo Moraes
Ana Clara Frony
Aline Maria Dias
Mariana Renovato-Martins
Genilson Rodrigues
Cezary Marcinkiewicz
Jamil Assreuy
Christina Barja-Fidalgo
Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
Data in Brief
author_facet João Alfredo Moraes
Ana Clara Frony
Aline Maria Dias
Mariana Renovato-Martins
Genilson Rodrigues
Cezary Marcinkiewicz
Jamil Assreuy
Christina Barja-Fidalgo
author_sort João Alfredo Moraes
title Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_short Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_full Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_fullStr Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_full_unstemmed Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_sort data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin ii effects in vascular smooth muscle cells
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2016-03-01
description The data provides information in support of the research article Moraes et al., Atherosclerosis 243(2) (2015) 477–485 [1]. Here we provide data behind the mechanisms involved in Angiotensin II (Ang II) effects on vascular smooth muscle cells (VSMC). Ang II-induced VSMC ROS production is modulated by alpha1beta1 integrin. Ang II also stimulates ROS production in VSMC via p47phox, a NOX2 subunit. Furthermore, Ang II effect on VSMC migration was also inhibited by NOX2 inhibitor. We showed that obtustatin, alpha1beta1 integrin blocker, inhibited Ang II effect on p47phox activation. Ang II effect on ROS production is also PI3K dependent. Finally we showed that NOX1 and Integrin-Linked-Kinase (ILK) are crucial to NOX2 activation. The research provides information about the sequential events of NOX1/alpha1beta1 integrin/ILK/NOX2 in Ang II effects on VSMC.
url http://www.sciencedirect.com/science/article/pii/S2352340915003480
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