Crystal structure of a 1:1 co-crystal of the anticancer drug gefitinib with azelaic acid

Crystal structure of a 1:1 co-crystal of the anticancer drug gefitinib with azelaic acid

In the title co-crystal, C22H24ClFN4O3·C9H16O4, gefitinib (GTB; systematic name: quinazolin-4-amine) co-crystallizes with azelaic acid (AA; systematic name: nonanedioic acid). The co-crystal has the monoclinic P21/n centrosymmetric space group, containing one molecule each of GTB and AA in the asymm...

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Bibliographic Details
Main Authors: Christy P. George, Ekta Sangtani, Rajesh G. Gonnade
Format: Article
Language:English
Published: International Union of Crystallography 2020-06-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
anticancer
azelaic acid
co-crystal
crystal structure
gefitinib
hydrogen bond
π–π interactions
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989020006623

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