A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach

A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/wa...

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Main Authors: André C. Sauer, Lucas Wolf, Natália Quoos, Mariele B. Rodrigues, Antônio L. Braga, Oscar E. D. Rodrigues, Luciano Dornelles
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2019/8589325
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spelling doaj-20376e453e59437dbf341eaea84b76852020-11-24T21:40:24ZengHindawi LimitedJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/85893258589325A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly ApproachAndré C. Sauer0Lucas Wolf1Natália Quoos2Mariele B. Rodrigues3Antônio L. Braga4Oscar E. D. Rodrigues5Luciano Dornelles6Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilDepartamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilDepartamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilDepartamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilDepartamento de Química, Universidade Federal de Santa Catarina, P.O Box 476, 88040-900 Florianópolis, SC, BrazilDepartamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilDepartamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, BrazilA straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/water as solvent in very short reaction times.http://dx.doi.org/10.1155/2019/8589325
collection DOAJ
language English
format Article
sources DOAJ
author André C. Sauer
Lucas Wolf
Natália Quoos
Mariele B. Rodrigues
Antônio L. Braga
Oscar E. D. Rodrigues
Luciano Dornelles
spellingShingle André C. Sauer
Lucas Wolf
Natália Quoos
Mariele B. Rodrigues
Antônio L. Braga
Oscar E. D. Rodrigues
Luciano Dornelles
A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
Journal of Chemistry
author_facet André C. Sauer
Lucas Wolf
Natália Quoos
Mariele B. Rodrigues
Antônio L. Braga
Oscar E. D. Rodrigues
Luciano Dornelles
author_sort André C. Sauer
title A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
title_short A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
title_full A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
title_fullStr A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
title_full_unstemmed A Straightforward and High-Yielding Synthesis of 1,2,4-Oxadiazoles from Chiral N-Protected α-Amino Acids and Amidoximes in Acetone-Water: An Eco-Friendly Approach
title_sort straightforward and high-yielding synthesis of 1,2,4-oxadiazoles from chiral n-protected α-amino acids and amidoximes in acetone-water: an eco-friendly approach
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2019-01-01
description A straightforward and high-yielding methodology for the synthesis of a high structural diversity of 1,2,4-oxadiazoles from different chiral N-protected α-amino acids and amidoximes under microwave (MW) irradiation is described herein. This greener approach gives the desired products using acetone/water as solvent in very short reaction times.
url http://dx.doi.org/10.1155/2019/8589325
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