Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

Age-related macular degeneration (AMD) damages the retinal pigment epithelium (RPE), the tissue that safeguards photoreceptor health, leading to irreversible vision loss. Polymorphisms in cholesterol and complement genes are implicated in AMD, yet mechanisms linking risk variants to RPE injury remai...

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Bibliographic Details
Main Authors: Nilsa La Cunza, Li Xuan Tan, Thushara Thamban, Colin J. Germer, Gurugirijha Rathnasamy, Kimberly A. Toops, Aparna Lakkaraju
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-05-01
Series:JCI Insight
Subjects:
Ophthalmology
Online Access:https://doi.org/10.1172/jci.insight.142254

Internet

https://doi.org/10.1172/jci.insight.142254

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