IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema.

IL-17A modulates oxidant stress-induced airway hyperresponsiveness but not emphysema.

IL-17A induces the release of pro-inflammatory cytokines and of reactive oxygen species which could lead to neutrophilic inflammation. We determined the role of IL-17 receptor (IL-17R) signalling in oxidant-induced lung emphysema and airway hyperresponsiveness. IL-17R(-/-) and wild-type C57/BL6 mice...

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Bibliographic Details
Main Authors:	Mariona Pinart, Min Zhang, Feng Li, Farhana Hussain, Jie Zhu, Coen Wiegman, Bernard Ryffel, Kian Fan Chung
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3594315?pdf=render

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