A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4

A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4

The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally ex...

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Main Authors: Siming Tang, Wanbiao Ma, Peifan Bai
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Computational and Mathematical Methods in Medicine
Online Access:http://dx.doi.org/10.1155/2017/5285810
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spelling doaj-20256787797b48bd80283d5176d836222020-11-24T23:12:03ZengHindawi LimitedComputational and Mathematical Methods in Medicine1748-670X1748-67182017-01-01201710.1155/2017/52858105285810A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4Siming Tang0Wanbiao Ma1Peifan Bai2Department of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, ChinaDepartment of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, ChinaDepartment of Applied Mathematics, School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, ChinaThe Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.http://dx.doi.org/10.1155/2017/5285810
collection DOAJ
language English
format Article
sources DOAJ
author Siming Tang
Wanbiao Ma
Peifan Bai
spellingShingle Siming Tang
Wanbiao Ma
Peifan Bai
A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
Computational and Mathematical Methods in Medicine
author_facet Siming Tang
Wanbiao Ma
Peifan Bai
author_sort Siming Tang
title A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
title_short A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
title_full A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
title_fullStr A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
title_full_unstemmed A Novel Dynamic Model Describing the Spread of the MERS-CoV and the Expression of Dipeptidyl Peptidase 4
title_sort novel dynamic model describing the spread of the mers-cov and the expression of dipeptidyl peptidase 4
publisher Hindawi Limited
series Computational and Mathematical Methods in Medicine
issn 1748-670X
1748-6718
publishDate 2017-01-01
description The Middle East respiratory syndrome (MERS) coronavirus, a newly identified pathogen, causes severe pneumonia in humans. MERS is caused by a coronavirus known as MERS-CoV, which attacks the respiratory system. The recently defined receptor for MERS-CoV, dipeptidyl peptidase 4 (DPP4), is generally expressed in endothelial and epithelial cells and has been shown to be present on cultured human nonciliated bronchiolar epithelium cells. In this paper, a class of novel four-dimensional dynamic model describing the infection of MERS-CoV is given, and then global stability of the equilibria of the model is discussed. Our results show that the spread of MERS-CoV can also be controlled by decreasing the expression rate of DPP4.
url http://dx.doi.org/10.1155/2017/5285810
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