The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain
Little is known about the molecular and cellular mechanisms involved in the formation of the cranial peripheral sensory system in vertebrates. To identify genes involved in the formation of these circuits, we performed a forward genetic screen utilizing a transgenic zebrafish line (p2rx3.2:gfpsl1) t...
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Neural Circuits |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncir.2019.00014/full |
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doaj-20221b27049f4f438505f44aa389ff4d2020-11-24T22:05:35ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102019-03-011310.3389/fncir.2019.00014435807The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the HindbrainJane A. CoxMark M. VoigtLittle is known about the molecular and cellular mechanisms involved in the formation of the cranial peripheral sensory system in vertebrates. To identify genes involved in the formation of these circuits, we performed a forward genetic screen utilizing a transgenic zebrafish line (p2rx3.2:gfpsl1) that expresses green fluorescent protein (gfp) in sensory neurons of the Vth, VIIth, IXth and Xth cranial ganglia. Here, we describe a novel zebrafish mutant in which a missense mutation in the adam19b gene selectively affects the epibranchial sensory circuits.https://www.frontiersin.org/article/10.3389/fncir.2019.00014/fullaxon guidancesensory circuitszebrafishmetalloproteasecranial nerves |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jane A. Cox Mark M. Voigt |
| spellingShingle |
Jane A. Cox Mark M. Voigt The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain Frontiers in Neural Circuits axon guidance sensory circuits zebrafish metalloprotease cranial nerves |
| author_facet |
Jane A. Cox Mark M. Voigt |
| author_sort |
Jane A. Cox |
| title |
The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain |
| title_short |
The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain |
| title_full |
The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain |
| title_fullStr |
The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain |
| title_full_unstemmed |
The Metalloproteinase adam19b Is Required for Sensory Axon Guidance in the Hindbrain |
| title_sort |
metalloproteinase adam19b is required for sensory axon guidance in the hindbrain |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Neural Circuits |
| issn |
1662-5110 |
| publishDate |
2019-03-01 |
| description |
Little is known about the molecular and cellular mechanisms involved in the formation of the cranial peripheral sensory system in vertebrates. To identify genes involved in the formation of these circuits, we performed a forward genetic screen utilizing a transgenic zebrafish line (p2rx3.2:gfpsl1) that expresses green fluorescent protein (gfp) in sensory neurons of the Vth, VIIth, IXth and Xth cranial ganglia. Here, we describe a novel zebrafish mutant in which a missense mutation in the adam19b gene selectively affects the epibranchial sensory circuits. |
| topic |
axon guidance sensory circuits zebrafish metalloprotease cranial nerves |
| url |
https://www.frontiersin.org/article/10.3389/fncir.2019.00014/full |
| work_keys_str_mv |
AT janeacox themetalloproteinaseadam19bisrequiredforsensoryaxonguidanceinthehindbrain AT markmvoigt themetalloproteinaseadam19bisrequiredforsensoryaxonguidanceinthehindbrain AT janeacox metalloproteinaseadam19bisrequiredforsensoryaxonguidanceinthehindbrain AT markmvoigt metalloproteinaseadam19bisrequiredforsensoryaxonguidanceinthehindbrain |
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