C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta

C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta

C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive deficits in two Alzheimer's Disease (AD) mouse...

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Bibliographic Details
Main Authors:	Michael X. Hernandez, Pouya Namiranian, Eric Nguyen, Maria I. Fonseca, Andrea J. Tenner
Format:	Article
Language:	English
Published:	SAGE Publishing 2017-01-01
Series:	ASN Neuro
Online Access:	https://doi.org/10.1177/1759091416687871

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