C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta
C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 antagonist, PMX205, decreased amyloid pathology and suppressed cognitive deficits in two Alzheimer's Disease (AD) mouse...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2017-01-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1177/1759091416687871 |