Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo

Pathogen-induced infectious diseases pose great threats to public health. Accordingly, many studies have investigated effective strategies targeting pathogenic infections. We previously reported the preventive effects of Lactobacillus plantarum ZS2058 (ZS2058) and L. rhamnosus GG (LGG) against Salmo...

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Main Authors:	Junsheng Liu, Zhennan Gu, Fanfen Song, Hao Zhang, Jianxin Zhao, Wei Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-02-01
Series:	Frontiers in Microbiology
Subjects:	Lactobacillus Salmonella preventive effect different mechanism
Online Access:	https://www.frontiersin.org/article/10.3389/fmicb.2019.00299/full

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record_format	Article
spelling	doaj-201c6e36ab00452b86d959bd84de3f552020-11-24T21:42:46ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-02-011010.3389/fmicb.2019.00299415382Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivoJunsheng Liu0Junsheng Liu1Junsheng Liu2Zhennan Gu3Zhennan Gu4Fanfen Song5Fanfen Song6Hao Zhang7Hao Zhang8Hao Zhang9Jianxin Zhao10Jianxin Zhao11Wei Chen12Wei Chen13Wei Chen14Wei Chen15State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaNational Engineering Research Center for Functional Food, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaNational Engineering Research Center for Functional Food, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaSchool of Food Science and Technology, Jiangnan University, Wuxi, ChinaNational Engineering Research Center for Functional Food, Jiangnan University, Wuxi, ChinaBeijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, ChinaPathogen-induced infectious diseases pose great threats to public health. Accordingly, many studies have investigated effective strategies targeting pathogenic infections. We previously reported the preventive effects of Lactobacillus plantarum ZS2058 (ZS2058) and L. rhamnosus GG (LGG) against Salmonella spp. in a murine model. Here, we compared the mechanisms underlying the preventive effects of these Lactobacillus strains in vivo. Notably, reduced C-reactive protein levels were observed with both ZS2058 and LGG, which suggests abrogated anti-infection and inflammatory responses. ZS2058 more efficiently reduced the pathogenicity of Salmonella by increasing the level of propionic acid in feces and production of mucin 2 in the mouse colon and activity through the interleukin (IL)-23/IL-22 and IL-23/IL-17 pathways. Meanwhile, LGG more strongly alleviated gut inflammation, as indicated by changes in the levels of tissue necrosis factor (TNF)-α, IL-10 and myeloperoxidase (MPO) in infected mice. Moreover, both ZS2058 and LGG restored the levels of interferon (INF)-γ, a cytokine suppressed by Salmonella, albeit through different pathways. Our results demonstrate that ZS2058 and LGG prevent Salmonella infection via different mechanisms.https://www.frontiersin.org/article/10.3389/fmicb.2019.00299/fullLactobacillusSalmonellapreventive effectdifferentmechanism
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Junsheng Liu Junsheng Liu Junsheng Liu Zhennan Gu Zhennan Gu Fanfen Song Fanfen Song Hao Zhang Hao Zhang Hao Zhang Jianxin Zhao Jianxin Zhao Wei Chen Wei Chen Wei Chen Wei Chen
spellingShingle	Junsheng Liu Junsheng Liu Junsheng Liu Zhennan Gu Zhennan Gu Fanfen Song Fanfen Song Hao Zhang Hao Zhang Hao Zhang Jianxin Zhao Jianxin Zhao Wei Chen Wei Chen Wei Chen Wei Chen Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo Frontiers in Microbiology Lactobacillus Salmonella preventive effect different mechanism
author_facet	Junsheng Liu Junsheng Liu Junsheng Liu Zhennan Gu Zhennan Gu Fanfen Song Fanfen Song Hao Zhang Hao Zhang Hao Zhang Jianxin Zhao Jianxin Zhao Wei Chen Wei Chen Wei Chen Wei Chen
author_sort	Junsheng Liu
title	Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
title_short	Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
title_full	Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
title_fullStr	Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
title_full_unstemmed	Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo
title_sort	lactobacillus plantarum zs2058 and lactobacillus rhamnosus gg use different mechanisms to prevent salmonella infection in vivo
publisher	Frontiers Media S.A.
series	Frontiers in Microbiology
issn	1664-302X
publishDate	2019-02-01
description	Pathogen-induced infectious diseases pose great threats to public health. Accordingly, many studies have investigated effective strategies targeting pathogenic infections. We previously reported the preventive effects of Lactobacillus plantarum ZS2058 (ZS2058) and L. rhamnosus GG (LGG) against Salmonella spp. in a murine model. Here, we compared the mechanisms underlying the preventive effects of these Lactobacillus strains in vivo. Notably, reduced C-reactive protein levels were observed with both ZS2058 and LGG, which suggests abrogated anti-infection and inflammatory responses. ZS2058 more efficiently reduced the pathogenicity of Salmonella by increasing the level of propionic acid in feces and production of mucin 2 in the mouse colon and activity through the interleukin (IL)-23/IL-22 and IL-23/IL-17 pathways. Meanwhile, LGG more strongly alleviated gut inflammation, as indicated by changes in the levels of tissue necrosis factor (TNF)-α, IL-10 and myeloperoxidase (MPO) in infected mice. Moreover, both ZS2058 and LGG restored the levels of interferon (INF)-γ, a cytokine suppressed by Salmonella, albeit through different pathways. Our results demonstrate that ZS2058 and LGG prevent Salmonella infection via different mechanisms.
topic	Lactobacillus Salmonella preventive effect different mechanism
url	https://www.frontiersin.org/article/10.3389/fmicb.2019.00299/full
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Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo

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