Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.

Bibliographic Details
Main Authors: Yu-Jie Li, Yu-Lu Cao, Jian-Xiong Feng, Yuanbo Qi, Shuxia Meng, Jie-Feng Yang, Ya-Ting Zhong, Sisi Kang, Xiaoxue Chen, Lan Lan, Li Luo, Bing Yu, Shoudeng Chen, David C. Chan, Junjie Hu, Song Gao
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12912-0
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spelling doaj-20184dcb3f0a4e0db34a9f78850e0d8f2021-05-11T12:33:44ZengNature Publishing GroupNature Communications2041-17232019-10-0110111410.1038/s41467-019-12912-0Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onsetYu-Jie Li0Yu-Lu Cao1Jian-Xiong Feng2Yuanbo Qi3Shuxia Meng4Jie-Feng Yang5Ya-Ting Zhong6Sisi Kang7Xiaoxue Chen8Lan Lan9Li Luo10Bing Yu11Shoudeng Chen12David C. Chan13Junjie Hu14Song Gao15State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Genetics and Cell Biology, College of Life Sciences, Nankai UniversityDivision of Biology and Biological Engineering, California Institute of TechnologyState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Experimental Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth affiliated Hospital, Sun Yat-sen UniversityDepartment of Experimental Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth affiliated Hospital, Sun Yat-sen UniversityNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Experimental Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth affiliated Hospital, Sun Yat-sen UniversityDivision of Biology and Biological Engineering, California Institute of TechnologyDepartment of Genetics and Cell Biology, College of Life Sciences, Nankai UniversityState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterMitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.https://doi.org/10.1038/s41467-019-12912-0
collection DOAJ
language English
format Article
sources DOAJ
author Yu-Jie Li
Yu-Lu Cao
Jian-Xiong Feng
Yuanbo Qi
Shuxia Meng
Jie-Feng Yang
Ya-Ting Zhong
Sisi Kang
Xiaoxue Chen
Lan Lan
Li Luo
Bing Yu
Shoudeng Chen
David C. Chan
Junjie Hu
Song Gao
spellingShingle Yu-Jie Li
Yu-Lu Cao
Jian-Xiong Feng
Yuanbo Qi
Shuxia Meng
Jie-Feng Yang
Ya-Ting Zhong
Sisi Kang
Xiaoxue Chen
Lan Lan
Li Luo
Bing Yu
Shoudeng Chen
David C. Chan
Junjie Hu
Song Gao
Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
Nature Communications
author_facet Yu-Jie Li
Yu-Lu Cao
Jian-Xiong Feng
Yuanbo Qi
Shuxia Meng
Jie-Feng Yang
Ya-Ting Zhong
Sisi Kang
Xiaoxue Chen
Lan Lan
Li Luo
Bing Yu
Shoudeng Chen
David C. Chan
Junjie Hu
Song Gao
author_sort Yu-Jie Li
title Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
title_short Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
title_full Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
title_fullStr Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
title_full_unstemmed Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset
title_sort structural insights of human mitofusin-2 into mitochondrial fusion and cmt2a onset
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Here, authors report crystal structures of truncated human MFN2 in different nucleotide-loading states and show that MFN2 forms sustained dimers even after GTP hydrolysis.
url https://doi.org/10.1038/s41467-019-12912-0
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