Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice

Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We...

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Bibliographic Details
Main Authors: Allison R. Rogala, Alexi A. Schoenborn, Brian E. Fee, Viviana A. Cantillana, Maria J. Joyce, Raad Z. Gharaibeh, Sayanty Roy, Anthony A. Fodor, R. Balfour Sartor, Gregory A. Taylor, Ajay S. Gulati
Format: Article
Language:English
Published: The Company of Biologists 2018-02-01
Series:Disease Models & Mechanisms
Subjects:
Immunity-related GTPases
Experimental colitis
Inflammatory bowel diseases
Online Access:http://dmm.biologists.org/content/11/2/dmm031070

Internet

http://dmm.biologists.org/content/11/2/dmm031070

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