Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys

Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys

ABSTRACT: The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods...

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Main Authors: Yasuyuki Shiigi, Jun-ichi Maeda, Hiroshi Yasumatsu, Hiroshi Tanaka, Daniel E. Casey
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319325873
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spelling doaj-2013413d765344089ccb092ed7c164932020-11-24T23:52:10ZengElsevierJournal of Pharmacological Sciences1347-86132003-01-01933364366Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus MonkeysYasuyuki Shiigi0Jun-ichi Maeda1Hiroshi Yasumatsu2Hiroshi Tanaka3Daniel E. Casey4Research Laboratory I (CNS), Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation, 7-25, Koyata 3-Chome, Iruma, Saitama 358-0026, JapanResearch Laboratory I (CNS), Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation, 7-25, Koyata 3-Chome, Iruma, Saitama 358-0026, JapanResearch Laboratory I (CNS), Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation, 7-25, Koyata 3-Chome, Iruma, Saitama 358-0026, JapanResearch Laboratory I (CNS), Pharmaceuticals Research Unit, Research & Development Division, Mitsubishi Pharma Corporation, 7-25, Koyata 3-Chome, Iruma, Saitama 358-0026, JapanMental Health Division (P3MIRECC), Veterans Affairs Medical Center, 3710 SW, US Veterans Hospital Road, Portland, OR 97239, USAABSTRACT: The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods at doses greater than 0.1 mg/kg, i.m. Although Y-931 significantly increased total dystonia scores (the sum of 15 to 360 min after injection) at doses greater than 0.5 mg/kg, i.m., the scores did not exceed 20, up to a dose of 1.0 mg/kg, i.m. and lacked a dose-response relationship. The present result suggests that Y-931 is predicted to have a low risk of extrapyramidal side effects.http://www.sciencedirect.com/science/article/pii/S1347861319325873
collection DOAJ
language English
format Article
sources DOAJ
author Yasuyuki Shiigi
Jun-ichi Maeda
Hiroshi Yasumatsu
Hiroshi Tanaka
Daniel E. Casey
spellingShingle Yasuyuki Shiigi
Jun-ichi Maeda
Hiroshi Yasumatsu
Hiroshi Tanaka
Daniel E. Casey
Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys
Journal of Pharmacological Sciences
author_facet Yasuyuki Shiigi
Jun-ichi Maeda
Hiroshi Yasumatsu
Hiroshi Tanaka
Daniel E. Casey
author_sort Yasuyuki Shiigi
title Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys
title_short Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys
title_full Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys
title_fullStr Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys
title_full_unstemmed Effect of a Novel Potential Atypical Antipsychotic Drug, Y-931, in Producing Dystonia in Cebus Monkeys
title_sort effect of a novel potential atypical antipsychotic drug, y-931, in producing dystonia in cebus monkeys
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2003-01-01
description ABSTRACT: The effect of Y-931 (8-fluoro-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine maleate), a novel potential atypical antipsychotic candidate, in producing dystonia in Cebus monkeys was investigated. Y-931 induced relatively weak dystonia in several observation periods at doses greater than 0.1 mg/kg, i.m. Although Y-931 significantly increased total dystonia scores (the sum of 15 to 360 min after injection) at doses greater than 0.5 mg/kg, i.m., the scores did not exceed 20, up to a dose of 1.0 mg/kg, i.m. and lacked a dose-response relationship. The present result suggests that Y-931 is predicted to have a low risk of extrapyramidal side effects.
url http://www.sciencedirect.com/science/article/pii/S1347861319325873
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