Radiation-induced spindle cell sarcoma: A rare case report

• Main Authors: Khan Mubeen, Chandramala Rupa, Sharma Ridhima, Vijayalakshmi K
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2009-01-01
• Series: Indian Journal of Dental Research
• Subjects: Ionizing radiations; retinoblastoma; spindle cell sarcomas
• Online Access: http://www.ijdr.in/article.asp?issn=0970-9290;year=2009;volume=20;issue=3;spage=380;epage=384;aulast=Khan

Ionizing radiation has been known to induce malignant transformation in human beings. Radiation-induced sarcomas are a late sequel of radiation therapy. Most sarcomas have been reported to occur after exposure to a radiation dose of 55 Gray (Gy) and above, with a dose ranging from 16 to 112 Gys. Spindle cell sarcomas, arising after radiotherapy given to treat the carcinoma of head and neck region is a very uncommon sequel. This is a rare case report of spindle cell sarcoma of left maxilla, in a 24-year-old male, occurring as a late complication of radiotherapy with Cobalt-60 given for the treatment of retinoblastoma of the left eye 21 years back.