1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction between a ligand and a protein and is now well-established as a screening technique for fragment-based lead discovery. Here we develop and assess a protocol to derive ligand epitope mapping from WaterLOGSY data and...

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Bibliographic Details
Main Authors: Claire Raingeval, Olivier Cala, Béatrice Brion, Marc Le Borgne, Roderick Eliot Hubbard, Isabelle Krimm
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
waterlogsy
solvent-exposed
saturation transfer difference
binding mode
fragment-based lead discovery
Online Access:http://dx.doi.org/10.1080/14756366.2019.1636235

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