Copy Number Signatures and Clinical Outcomes in Upper Tract Urothelial Carcinoma

Copy Number Signatures and Clinical Outcomes in Upper Tract Urothelial Carcinoma

Tumor staging of upper tract urothelial carcinomas (UTUCs) is relatively difficult to assert accurately before surgery. Here, we used copy number (CN) signatures as a tool to explore their clinical significance of molecular stratification in UTUC. CN signatures were extracted by non-negative matrix...

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Bibliographic Details
Main Authors: Bao Guan, Yuan Liang, Huan Lu, Zhengzheng Xu, Yue Shi, Juan Li, Wenwen Kong, Chuanyu Tian, Yezhen Tan, Yanqing Gong, Jin Liu, Dong Fang, Qi Shen, Shiming He, Muhammad Shakeel, Zhongyuan Zhang, Qun He, Xuesong Li, Weimin Ci, Liqun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
upper tract urothelial carcinoma
whole-genome sequencing
copy number signature
prognosis
cell-free DNA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.713499/full

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