RNA binding proteins co-localize with small tau inclusions in tauopathy

RNA binding proteins co-localize with small tau inclusions in tauopathy

Abstract The development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer’s disease (AD). Accumulating evidence suggests that tau pathology co-localizes with RNA binding proteins (RBPs) th...

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Bibliographic Details
Main Authors: Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E. A. Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F. Abisambra, Hu Li, Benjamin Wolozin
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Neurofibrillary tangle
Immunohistochemistry
Mass spectrometry
Protein interactome
Protein aggregation
Online Access:http://link.springer.com/article/10.1186/s40478-018-0574-5

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